जैव सूचना विज्ञान

112 विधियाँ इस परिवार में।

विशेष रूप से चयनित

मिश्रण विश्लेषणAdmixture analysis is a population genetics method that infers population structure and individual ancestry from multilocus genotype data. Originally developed by Pritchard, Stephe पूर्वज अवस्था पुनर्निर्माणAncestral state reconstruction (ASR) is a phylogenetic method that infers the character states (trait values or evolutionary features) of extinct ancestors by analyzing patterns of ATAC-seq विश्लेषणATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is a method for profiling the landscape of chromatin accessibility genome-wide. Developed by Buenrostro and c ChIP-seq पीक कॉलिंगChIP-seq peak calling is a computational pipeline that identifies genomic regions where a protein of interest — a transcription factor or histone modification — is enriched, based सहसंयोजन सिद्धांतCoalescent theory is a probabilistic framework that traces the genealogical history of DNA sequences backward in time to their most recent common ancestor. Developed by John Kingma Copy Number Variation AnalysisCopy number variation (CNV) analysis is a genomic pipeline for detecting regions where individuals carry fewer or more copies of a DNA segment than the reference genome. CNVs span

अध्ययन पथ

इस विषय की सर्वाधिक उद्धृत आधारभूत पद्धतियाँ, उनके विकास के क्रम में — यदि आप यहाँ नए हैं तो आरम्भ करने का स्थान।

Copy Number Variation Analysis1998–2006Pinkel et al. (array CGH); Redon et al. (genome-wide CNV map) द्वारा
Pathway Enrichment Analysis2003–2005Mootha et al. (2003); systematised by Subramanian et al. (2005) द्वारा
जीन सेट एनरिचमेंट एनालिसिस (GSEA)2005 (seminal PNAS paper; predecessor concept in Mootha et al. 2003)Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Jill P. Mesirov, Todd R. Golub, Eric S. Lander et al. (Broad Institute) द्वारा
जीनोम-वाइड एसोसिएशन स्टडी (GWAS)2005–2007Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007) द्वारा
एपिजिनोम-वाइड एसोसिएशन स्टडी (EWAS)2008–2011 (term and framework established c. 2011)Rakyan, Down, Balding & Beck (conceptual framework); Illumina arrays enabled large-scale application द्वारा
आरएनए-सीक्वेंसिंग विभेदक अभिव्यक्ति2008–2010 (RNA-seq DE methodology established)Multiple groups; foundational methods from Anders & Huber (DESeq, 2010), Robinson, McCarthy & Smyth (edgeR, 2010) द्वारा
सिंगल-सेल आरएनए-सीक्वेंस विश्लेषण2009 (first scRNA-seq by Tang et al.); widely adopted 2015–2016Azim Surani, Barbara Treutlein, and the Regev/McCarroll groups (foundational droplet-based methods ~2015) द्वारा
Variant Calling2009–2010 (modern high-throughput era)Li et al. (SAMtools/bcftools, 2009); McKenna et al. (GATK, 2010) द्वारा

इस खण्ड की सभी पद्धतियाँ ↓

सभी विधियाँ 112

संकेत और वैज्ञानिक कंप्यूटिंग में और

संकेत और संख्यात्मकी 48