Process / pipelineBioinformatics / omics
时间序列全表观基因组关联研究 — 纵向EWAS
时间序列全表观基因组关联研究（time-series EWAS）将经典的横断面EWAS设计扩展到纵向研究，在同一受试者中于多个时间点测量整个表观基因组的DNA甲基化水平。其目标是识别甲基化水平随时间系统性变化的CpG位点，或表征表观遗传学与暴露或表型之间的关联如何随发育阶段、治疗期或疾病轨迹演变。
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来源
- Pidsley, R., Zotenko, E., Peters, T. J., Lawrence, M. G., Risbridger, G. P., Molloy, P., ... & Clark, S. J. (2016). Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biology, 17(1), 208. link ↗
- Waterland, R. A., Kellermayer, R., Laritsky, E., Rayco-Solon, P., Harris, R. A., Travisano, M., ... & Prentice, A. M. (2010). Season of conception in rural Gambia affects DNA methylation at putative human metastable epialleles. PLoS Genetics, 6(12), e1001252. link ↗
如何引用本页
ScholarGate. (2026, June 3). Longitudinal Epigenome-wide Association Study. ScholarGate. https://scholargate.app/zh/bioinformatics/time-series-epigenome-wide-association-study
选用哪种方法？
将本方法与其最相近的同类并置，并排研读——本馆将书籍铺陈于案上，取舍则由您定夺。
- 表观基因组关联研究 (EWAS)生物信息学↔ 比较
- RNA-seq差异表达生物信息学↔ 比较
- 单细胞时间序列RNA测序分析生物信息学↔ 比较
Similar methods
Differential Epigenome-Wide Association StudyEpigenome-wide association studyBayesian epigenome-wide association studyMulti-omics epigenome-wide association studyMachine learning-assisted epigenome-wide association studyBayesian epigenome-wide association study in educational researchEpigenome-wide association study in educational researchNetwork-based epigenome-wide association study