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Adaptive Randomized Controlled Trial — Adaptive RCT
An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.
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Sources
- Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690
- Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36. DOI: 10.1038/nrd1927 ↗
Related methods
Referenced by
Adaptive Control Group Experimental DesignAdaptive Field ExperimentAdaptive Laboratory ExperimentAdaptive Pretest-Posttest Experimental DesignBlocked Randomized Controlled TrialCluster Randomized Adaptive ExperimentCluster Randomized Multi-Arm ExperimentCrossover Adaptive ExperimentCrossover Randomized Controlled TrialDouble-blind adaptive experimentFactorial Randomized Controlled TrialPilot Randomized Controlled TrialPragmatic Randomized Controlled Trial