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自适应巢式病例对照研究

自适应巢式病例对照研究在既定队列中嵌入病例对照比较,并纳入预先指定的期中决策规则,允许根据累积数据进行修改——例如调整对照与病例的比例或修订生物标志物亚样本——而不会损害研究的有效性或增加I类错误。该设计结合了巢式病例对照框架的效率和自适应方法的灵活性,以在暴露评估成本高昂时优化资源利用。

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来源

  1. Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491. DOI: 10.2307/2345280
  2. Bauer, P., & Kohne, K. (1994). Evaluation of experiments with adaptive interim analyses. Biometrics, 50(4), 1029–1041. DOI: 10.2307/2533441

如何引用本页

ScholarGate. (2026, June 3). Adaptive Nested Case-Control Study. ScholarGate. https://scholargate.app/zh/epidemiology/adaptive-nested-case-control

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ScholarGateAdaptive nested case-control (Adaptive Nested Case-Control Study). 于 2026-06-15 检索自 https://scholargate.app/zh/epidemiology/adaptive-nested-case-control · 数据集: https://doi.org/10.5281/zenodo.20539026