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病例-交叉设计 — 瞬时暴露的自我匹配流行病学研究

病例-交叉设计是一种观察性流行病学方法,通过将每个病例在事件发生前短暂危险窗口期内的暴露与其自身在先前对照期内的暴露进行比较,来估计瞬时暴露是否会触发急性事件。由于每个人都充当自己的对照,所有稳定的个人特征都会被自动调整,这使得该设计在研究间歇性暴露和突发性结局(如心肌梗死、中风或损伤)方面特别强大。

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来源

  1. Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI: 10.1093/oxfordjournals.aje.a115853
  2. Mittleman, M. A., Maclure, M., & Robins, J. M. (1995). Control sampling strategies for case-crossover studies: An assessment of relative efficiency. American Journal of Epidemiology, 142(1), 91–98. DOI: 10.1093/oxfordjournals.aje.a117550

如何引用本页

ScholarGate. (2026, June 3). Case-Crossover Study Design. ScholarGate. https://scholargate.app/zh/epidemiology/case-crossover-design

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ScholarGateCase-crossover design (Case-Crossover Study Design). 于 2026-06-15 检索自 https://scholargate.app/zh/epidemiology/case-crossover-design · 数据集: https://doi.org/10.5281/zenodo.20539026