方法对比

	自适应巢式病例对照研究	病例-交叉设计
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	Base design 1977; adaptive extensions from 1990s onward	1991
提出者	Nested case-control: D. C. Thomas (1977); adaptive design framework: Peter Bauer & Klaus Kohne (1994)	Malcolm Maclure
类型	Observational epidemiological study with adaptive design elements	Observational epidemiological study design
开创性文献	Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491.	Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.
别名	adaptive NCC, adaptive nested case-referent study, dynamic nested case-control, sequential nested case-control	case-crossover study, CCO design, self-matched case study, within-person crossover case study
相关	6	3
摘要	An adaptive nested case-control study embeds a case-control comparison within a defined cohort and incorporates pre-specified interim decision rules that allow modifications — such as control-to-case ratio adjustment or biomarker sub-sampling revision — based on accumulating data, without compromising the study's validity or inflating type I error. The design combines the efficiency of the nested case-control framework with the flexibility of adaptive methodology to optimise resource use when exposure assessment is costly.	The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury.