Process / pipelineBioinformatics / omics
序列比对 — 生物序列比对
序列比对是一项基础的生物信息学技术，它排列两条或多条 DNA、RNA 或蛋白质序列，以揭示相似区域、推断进化关系、识别功能域以及将测序读段映射到参考基因组。从变异检测和基因表达量化到系统发育学和结构注释，几乎所有下游基因组分析都依赖于此。
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Method map
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来源
- Needleman, S. B., & Wunsch, C. D. (1970). A general method applicable to the search for similarities in the amino acid sequence of two proteins. Journal of Molecular Biology, 48(3), 443–453. DOI: 10.1016/0022-2836(70)90057-4 ↗
- Smith, T. F., & Waterman, M. S. (1981). Identification of common molecular subsequences. Journal of Molecular Biology, 147(1), 195–197. DOI: 10.1016/0022-2836(81)90087-5 ↗
如何引用本页
ScholarGate. (2026, June 3). Biological Sequence Alignment. ScholarGate. https://scholargate.app/zh/bioinformatics/sequence-alignment
Which method?
Set this method beside its closest kin and read them side by side — the library lays the books on the table; the choice is yours.
- ChIP-seq Peak Calling生物信息学↔ compare
- 全基因组关联研究 (GWAS)生物信息学↔ compare
- 系统发育分析生物信息学↔ compare
- RNA-seq差异表达生物信息学↔ compare
- Single-cell RNA-seq analysis生物信息学↔ compare
- 变异检测生物信息学↔ compare