Process / pipelineBiophysical diffusion modeling
NODDI
Neurite Orientation Dispersion and Density Imaging (NODDI) is a biophysical diffusion MRI model that quantifies microstructural properties of white matter: neurite density (axonal density), orientation dispersion (fiber coherence), and isotropic diffusion (free water or cerebrospinal fluid). Introduced by Zhang and colleagues in 2012, NODDI provides biologically interpretable metrics directly linking diffusion MRI signals to tissue microstructure.
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Sources
- Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012). NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage, 61(4), 1000–1016. DOI: 10.1016/j.neuroimage.2012.03.072 ↗
- Alexander, D. C., Dyrby, T. B., Nilsson, M., & Zhang, H. (2019). Imaging brain microstructure with diffusion MRI: practical clinical applications. Nature Reviews Neurology, 15(10), 591–606. DOI: 10.1038/s41582-019-0250-9 ↗