Process / pipelineSpectral power analysis
Amplitude of Low-Frequency Fluctuation
Amplitude of Low-Frequency Fluctuation (ALFF) is a resting-state fMRI metric that quantifies the strength of spontaneous low-frequency oscillations (typically 0.01–0.1 Hz) in the brain. Introduced by Yang and colleagues in 2007, ALFF provides a voxel-wise measure of local brain activity, reflecting the amplitude of spontaneous fluctuations in blood oxygen levels at rest.
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Sources
- Yang, H., Long, X. Y., Yang, Y., et al. (2007). Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. NeuroImage, 36(4), 773–781. DOI: 10.1016/j.neuroimage.2007.02.006 ↗
- Zou, Q. H., Zhu, C. Z., Yang, Y., et al. (2008). An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. Journal of Neuroscience Methods, 172(1), 137–141. DOI: 10.1016/j.jneumeth.2008.04.012 ↗