Process / pipelineMyelin-sensitive MRI
Magnetisation Transfer Ratio
Magnetisation Transfer Ratio (MTR) is an MRI method that measures the exchange of magnetization between free water protons and protons bound to macromolecules (primarily myelin lipids and proteins). Introduced by Wolff and Balaban in 1989, MTR reflects tissue macromolecular content and is particularly sensitive to myelination, providing a non-invasive estimate of myelin density.
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Sources
- Wolff, S. D., & Balaban, R. S. (1989). Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Journal of Magnetic Resonance Imaging, 10(2), 135–148. DOI: 10.1002/(SICI)1522-2586(199202)10:2<135::AID-JMRI5>3.0.CO;2-8 ↗
- Henkelman, R. M., Huang, X., Lago, A., & Stanisz, G. J. (1993). Quantitative interpretation of magnetization transfer. Magnetic Resonance in Medicine, 29(6), 759–766. DOI: 10.1002/mrm.1910290607 ↗