Process / pipelineGenomic variation analysis
LD区块分析
连锁不平衡（LD）区块分析是一种基因组学方法，它将人类基因组划分为不同的单倍型区块——重组受限的区域，其中变异具有强烈的统计关联。该方法由Gabriel及其同事于2002年首次系统性描述，揭示了遗传变异的潜在结构，并通过减少捕获常见多样性所需的变异数量，实现了高效的基因组学研究。LD区块分析是全基因组关联研究（GWAS）设计和现代群体遗传学的基础。
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来源
- Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229. DOI: 10.1126/science.1069424 ↗
- Daly, M. J., Rioux, J. D., Schaffner, S. F., Hudson, T. J., & Lander, E. S. (2001). High-resolution haplotype structure in the human genome. Nature Genetics, 29(2), 229–232. DOI: 10.1038/ng1001-229 ↗
- Wang, N., Akey, J. M., Zhang, K., Chakraborty, R., & Jin, L. (2005). Distribution of recombination crossovers and the origin of block-like patterns of linkage disequilibrium. Genetics, 155(4), 1599–1606. link ↗
如何引用本页
ScholarGate. (2026, June 3). Linkage Disequilibrium Block Analysis and Haplotype Mapping. ScholarGate. https://scholargate.app/zh/genetics/ld-block-analysis
Which method?
Set this method beside its closest kin and read them side by side — the library lays the books on the table; the choice is yours.
- 混合分析 (Admixture Analysis)遗传学↔ compare
- F统计量 (FST)遗传学↔ compare
- IBD Mapping遗传学↔ compare
- 多基因风险评分遗传学↔ compare
- QTL作图遗传学↔ compare