Process / pipelineQuantitative genetics
QTL作图
定量性状基因座 (QTL) 作图是一种遗传学方法，用于定位影响定量性状的染色体区域——定量性状是由多个基因和环境因素控制的连续表型。QTL作图由Lander和Botstein于1989年开发，利用连锁分析和分离群体（如F2杂交或重组自交系）中的性状变异，来识别含有显著影响性状值的基因座的基因组区间。这种基础方法已被扩展到全基因组关联分析，对于理解复杂性状的遗传结构至关重要。
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来源
- Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199. link ↗
- Haley, C. S., & Knott, S. A. (1992). A simple regression method for mapping quantitative trait loci using molecular markers. Heredity, 69(4), 315–324. DOI: 10.1038/hdy.1992.131 ↗
- Kao, C. H., Zeng, Z. B., & Teasdale, R. D. (1999). Multiple interval mapping for quantitative trait loci. Genetics, 152(3), 1203–1216. DOI: 10.1093/genetics/152.3.1203 ↗
如何引用本页
ScholarGate. (2026, June 3). Quantitative Trait Loci Mapping for Complex Trait Dissection. ScholarGate. https://scholargate.app/zh/genetics/qtl-mapping
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