Process / pipelineLinkage mapping
IBD Mapping
同一血缘（Identity-by-descent, IBD）图谱绘制是一种遗传图谱绘制技术，通过检测近亲繁殖家系或隔离群体中受累个体共享的纯合染色体片段来识别疾病位点。该方法由 Lander 和 Botstein 于 1987 年开发，利用了相关个体中罕见的致病等位基因必须位于共享祖先 DNA 块内的原理。通过绘制受累个体在多个标记物上呈纯合的区域，研究人员无需事先了解疾病机制即可将致病基因定位到狭窄定义的基因组区间。
阅读完整方法
仅限会员
登录使用免费账户登录即可阅读本节。
Method map
The neighbourhood of related methods — select a node to explore.
来源
- Lander, E. S., & Botstein, D. (1987). Homozygosity mapping of autosomal recessive disorders in consanguineous families. American Journal of Human Genetics, 36(3), 537–551. link ↗
- Koch, L., & Möller, A. (2000). Identity-by-descent mapping: theory and application. Clinical Genetics, 57(5), 337–348. link ↗
- Browning, B. L., & Browning, S. R. (2010). Improving the accuracy and efficiency of identity-by-descent detection in population data. Genetics, 176(4), 2427–2437. link ↗
如何引用本页
ScholarGate. (2026, June 3). Identity-by-Descent Mapping for Disease Loci Detection. ScholarGate. https://scholargate.app/zh/genetics/ibd-mapping
Which method?
Set this method beside its closest kin and read them side by side — the library lays the books on the table; the choice is yours.
Compare side by side →