Hypothesis test
自适应临床试验设计
自适应临床试验设计是一种灵活的实验框架，由 Bauer 和 Köhne 于 1994 年正式提出，其中预先设定的规则允许在试验过程中根据累积的期中数据对试验进行修改——调整样本量、治疗组或随机化比例——同时严格控制第一类错误率。
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来源
- Bauer, P. & Köhne, K. (1994). Evaluation of Experiments with Adaptive Interim Analyses. Biometrics, 50(4), 1029–1041. DOI: 10.2307/2533441 ↗
- FDA (2019). Adaptive Design Clinical Trials for Drugs and Biologics — Guidance for Industry. U.S. Food and Drug Administration. link ↗
如何引用本页
ScholarGate. (2026, June 1). Adaptive Design for Clinical Trials. ScholarGate. https://scholargate.app/zh/experimental-design/adaptive-design
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