Hypothesis test
顺序/分组顺序试验设计
顺序和分组顺序试验设计允许根据进行的期中分析提前终止研究——或继续进行——随着数据的累积。其核心框架由 O'Brien 和 Fleming 于 1979 年正式确立，并由 Lan 和 DeMets 的 alpha 支出方法进行了扩展，它通过在招募开始前预先指定疗效和无效性边界来控制所有计划的检查点之间的总体第一类错误率。
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来源
- O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556. DOI: 10.2307/2530245 ↗
- Jennison, C. & Turnbull, B.W. (2000). Group Sequential Methods with Applications to Clinical Trials. CRC Press. ISBN: 978-0849303166
如何引用本页
ScholarGate. (2026, June 1). Sequential / Group Sequential Trial Design. ScholarGate. https://scholargate.app/zh/experimental-design/sequential-design
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