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差异通路富集分析

差异通路富集分析旨在识别在两种或多种实验条件(例如,两种疾病、两种治疗或两种细胞类型)之间富集信号存在显著差异的生物学通路。它不只是询问在某种条件下哪些通路富集,而是探究哪些通路在不同条件下富集水平表现出统计学意义上的变化,从而揭示条件特异性或背景依赖性的生物学机制。

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来源

  1. Wu, D., & Smyth, G. K. (2012). Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Research, 40(17), e133. DOI: 10.1093/nar/gks461
  2. Väremo, L., Nielsen, J., & Nookaew, I. (2013). Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical inferences. Nucleic Acids Research, 41(8), 4378–4391. DOI: 10.1093/nar/gkt111

如何引用本页

ScholarGate. (2026, June 3). Differential Pathway Enrichment Analysis. ScholarGate. https://scholargate.app/zh/bioinformatics/differential-pathway-enrichment-analysis

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并排比较
ScholarGateDifferential pathway enrichment analysis (Differential Pathway Enrichment Analysis). 于 2026-06-17 检索自 https://scholargate.app/zh/bioinformatics/differential-pathway-enrichment-analysis · 数据集: https://doi.org/10.5281/zenodo.20539026