方法对比
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| 差异通路富集分析× | 通路富集分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2004–2012 | 2003–2005 |
| 提出者≠ | Extended from Over-Representation Analysis (Draghici et al. 2003) and competitive gene-set testing (Smyth lab, ~2004–2012) | Mootha et al. (2003); systematised by Subramanian et al. (2005) |
| 类型≠ | Comparative enrichment analysis | Statistical functional annotation method |
| 开创性文献≠ | Wu, D., & Smyth, G. K. (2012). Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Research, 40(17), e133. DOI ↗ | Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550. DOI ↗ |
| 别名 | differential enrichment analysis, comparative pathway enrichment, DPEA, cross-condition pathway analysis | PEA, overrepresentation analysis, ORA, functional enrichment analysis |
| 相关≠ | 5 | 6 |
| 摘要≠ | Differential pathway enrichment analysis identifies biological pathways whose enrichment signals differ significantly between two or more experimental conditions — for example, between two diseases, two treatments, or two cell types. Rather than asking which pathways are enriched in one condition, it asks which pathways show a statistically meaningful change in enrichment level across conditions, revealing condition-specific or context-dependent biology. | Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments. |
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