Process / pipelineFunctional genomics

Analiza CRISPR zaslona

Analiza CRISPR zaslona obrađuje podatke iz skupnih genetičkih zaslona pomoću CRISPR-Cas9 kako bi se identificirali geni potrebni za rast stanica, preživljavanje ili fenotip u specifičnim uvjetima. Razvijen od strane Zhanga, Sanjane i drugih, ovaj računalni cjevovod pretvara sekvencijske izlaze obilja RNA vodilica u rangirane popise funkcionalnih gena.

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Izvori

  1. Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., ... & Zhang, F. (2014). Genome-scale CRISPR-Cas9 knockout screening in human cells. Science, 343(6166), 84-87. DOI: 10.1126/science.1247005
  2. Hart, T., Chandrashekhar, M., Aregger, M., Steinhart, Z., Brown, K. R., MacLeod, G., ... & Moffat, J. (2015). High-resolution CRISPR screens reveal fitness genes and pathways. Molecular Systems Biology, 11(8), 820. link
  3. King, J. B., Palmer, A. C., & Sorger, P. K. (2020). Application of a genetic algorithm designed for flexible objective optimization in pharmaceutical research and development. Cancer Research, 79(13 Supplement), 3435. link

Kako citirati ovu stranicu

ScholarGate. (2026, June 3). CRISPR Screening Data Analysis and Hit Identification. ScholarGate. https://scholargate.app/hr/bioinformatics/crispr-screen-analysis

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Set this method beside its closest kin and read them side by side — the library lays the books on the table; the choice is yours.

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Citirana u

ScholarGateCRISPR Screen Analysis (CRISPR Screening Data Analysis and Hit Identification). Preuzeto 2026-06-15 s https://scholargate.app/hr/bioinformatics/crispr-screen-analysis · Skup podataka: https://doi.org/10.5281/zenodo.20539026