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网络驱动的 eQTL 分析 — 网络整合的表达数量性状基因座定位

网络驱动的 eQTL 分析通过将遗传变异与表达的关联嵌入基因调控或蛋白质互作网络中,扩展了经典的 eQTL 定位方法。该方法不独立处理每个 SNP-基因对,而是利用网络拓扑结构(如共表达模块或已知通路结构)来提高统计功效、减轻多重检验负担,并揭示遗传变异如何扰乱整个调控程序而非孤立的转录本。

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来源

  1. Skinner, M. E., Uzilov, A. V., Stein, L. D., Mungall, C. J., & Holmes, I. H. (2009). JBrowse: a next-generation genome browser. Genome Research, 19(9), 1630–1638. link
  2. Zhang, B., & Horvath, S. (2005). A general framework for weighted gene co-expression network analysis. Statistical Applications in Genetics and Molecular Biology, 4(1), Article17. link

如何引用本页

ScholarGate. (2026, June 3). Network-based Expression Quantitative Trait Loci Analysis. ScholarGate. https://scholargate.app/zh/bioinformatics/network-based-eqtl-analysis

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被引用于

ScholarGateNetwork-based eQTL analysis (Network-based Expression Quantitative Trait Loci Analysis). 于 2026-06-15 检索自 https://scholargate.app/zh/bioinformatics/network-based-eqtl-analysis · 数据集: https://doi.org/10.5281/zenodo.20539026