Process / pipelinePharmacodynamics
Isobologram Analysis
Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic.
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Sources
- Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334. link ↗
- Bliss, C. I. (1939). The toxicity of poisons applied jointly. Annals of Applied Biology, 26(3), 585-615. DOI: 10.1111/j.1744-7348.1939.tb06990.x ↗