Process / pipelineUltrasound imaging
Functional Ultrasound
Functional Ultrasound (fUS) is a high-framerate Doppler ultrasound technique that dynamically maps blood flow and hemodynamic changes in vivo with millisecond temporal resolution. Pioneered by Tanter, Macé, and colleagues in the 2010s, fUS enables real-time imaging of microvascular perfusion in the brain and other organs. By combining ultrafast acquisition (1000-5000 frames per second) with Doppler processing, fUS reveals functional activity (hemodynamic changes during stimulation or behavior) and vascular networks with unprecedented spatiotemporal detail.
Open in MethodMindSoonVideoSoon
Read the full method
Members only
Sign inSign in with a free account to read this section.
Sources
- Macé, E., Montaldo, G., Trenholm, S., et al. (2011). Functional ultrasound imaging of the brain. Nature Methods, 8(8), 662-664. DOI: 10.1038/nmeth.1641 ↗
- Tiran, E., Sieu, L. A., Bergel, A., et al. (2017). Multiplane wave imaging increases signal awareness for small vasculature imaging in mice and rats. IEEE Transactions on Medical Imaging, 36(11), 2371-2379. DOI: 10.1109/TMI.2017.2728726 ↗
- Errico, C., Pierre, J., Pezet, S., et al. (2015). Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature, 527(7579), 499-502. DOI: 10.1038/nature16373 ↗