NODDI
Neurite Orientation Dispersion and Density Imaging (NODDI) is a biophysical diffusion MRI model that quantifies microstructural properties of white matter: neurite density (axonal density), orientation dispersion (fiber coherence), and isotropic diffusion (free water or cerebrospinal fluid). Introduced by Zhang and colleagues in 2012, NODDI provides biologically interpretable metrics directly linking diffusion MRI signals to tissue microstructure.
Source record
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- Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012). NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage, 61(4), 1000–1016. · DOI 10.1016/j.neuroimage.2012.03.072
- Alexander, D. C., Dyrby, T. B., Nilsson, M., & Zhang, H. (2019). Imaging brain microstructure with diffusion MRI: practical clinical applications. Nature Reviews Neurology, 15(10), 591–606. · URL
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