Process / pipelineAdvanced Meta-Analysis

Network Meta-Analysis

Network meta-analysis (NMA) is a systematic method for comparing multiple interventions simultaneously within a single analytical framework, incorporating both direct evidence (head-to-head trials) and indirect evidence (comparisons via common comparators). First formalized by Lumley in 2002, NMA allows researchers to rank treatments and quantify comparative effectiveness even when some treatment pairs have never been directly studied.

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Sources

  1. Lumley, T. (2002). Network meta-analysis for indirect treatment comparisons. Statistics in Medicine, 21(16), 2313–2324. DOI: 10.1002/sim.1201
  2. Bucher, H. C., Guyatt, G. H., Griffith, L. E., & Walter, S. D. (1997). The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. Journal of Clinical Epidemiology, 50(6), 683–691. DOI: 10.1016/s0895-4356(97)00049-8
  3. Dias, S., Welton, N. J., Caldwell, D. M., & Ades, A. E. (2010). Checking consistency in mixed treatment comparison meta-analysis. Statistics in Medicine, 29(7–8), 932–944. DOI: 10.1002/sim.3767

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Referenced by

ScholarGateNetwork Meta-Analysis (Network Meta-Analysis (NMA)). Retrieved 2026-06-04 from https://scholargate.app/en/evidence-synthesis/network-meta-analysis