Process / pipelineClinical / epidemiology

Meta-analytic Dose-Response Analysis

Meta-analytic dose-response analysis pools summary statistics from multiple epidemiological studies to characterize how disease risk changes across ordered levels of an exposure. Rather than comparing a single high-exposure group against a reference, it reconstructs a continuous or categorical exposure-risk curve across the full range of doses, providing far richer evidence about the shape and magnitude of an association than any single study can supply.

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Sources

  1. Greenland, S., & Longnecker, M. P. (1992). Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. American Journal of Epidemiology, 135(11), 1301–1309. DOI: 10.1093/oxfordjournals.aje.a116237
  2. Orsini, N., Li, R., Wolk, A., Khudyakov, P., & Spiegelman, D. (2012). Meta-analysis for linear and nonlinear dose-response relations: Examples, an evaluation of approximations, and software. American Journal of Epidemiology, 175(1), 66–73. DOI: 10.1093/aje/kwr265

Related methods

ScholarGateMeta-analytic dose-response analysis (Meta-analytic Dose-Response Analysis). Retrieved 2026-06-04 from https://scholargate.app/en/epidemiology/meta-analytic-dose-response-analysis