Process / pipelineClinical / epidemiology
Meta-analytic Randomized Clinical Trial — Pooling RCT Evidence
A meta-analytic randomized clinical trial is a formal evidence-synthesis method that identifies, appraises, and statistically combines the results of multiple randomized clinical trials addressing the same clinical question. By pooling trial-level data, it produces a single, more precise estimate of treatment effect and quantifies between-trial heterogeneity, sitting at the apex of the evidence hierarchy for evaluating healthcare interventions.
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Sources
- Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2019). Cochrane Handbook for Systematic Reviews of Interventions (2nd ed.). Wiley-Blackwell. ISBN: 978-1119536628
- Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to Meta-Analysis. Wiley. ISBN: 978-0470057247