Process / pipelineClinical / epidemiology
Dose-Response Analysis — Quantifying How Exposure Level Relates to Outcome Risk
Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.
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Sources
- Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
- Greenland, S., & Longnecker, M. P. (1992). Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. American Journal of Epidemiology, 135(11), 1301–1309. DOI: 10.1093/oxfordjournals.aje.a116237 ↗
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Referenced by
Adaptive Dose-Response AnalysisAdaptive Randomized Clinical TrialBayesian Phase I clinical trialBayesian Phase II Clinical TrialBayesian Screening Test EvaluationEcological StudyMatched dose-response analysisMulticenter Dose-Response AnalysisMulticenter Ecological StudyMulticenter Phase I Clinical TrialMulticenter Phase IV StudyPhase I Clinical TrialPhase II clinical trialPragmatic Dose-Response AnalysisPragmatic ecological studyPragmatic phase IV studyProspective Dose-Response AnalysisRetrospective Ecological StudyRisk-adjusted dose-response analysisRisk-adjusted Phase I clinical trialScreening Test Evaluation