Process / pipelineClinical / epidemiology
Adaptive Randomized Clinical Trial
An adaptive randomized clinical trial (adaptive RCT) is a prospective experimental study that uses pre-specified rules to modify one or more trial aspects — such as sample size, allocation ratios, or treatment arms — based on accumulating data collected during the trial itself, while maintaining statistical validity and integrity of the study.
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Sources
- Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36. DOI: 10.1038/nrd1927 ↗
- U.S. Food and Drug Administration. (2019). Adaptive Designs for Clinical Trials of Drugs and Biologics: Guidance for Industry. FDA. link ↗
Related methods
Referenced by
Adaptive case seriesAdaptive Case-Control StudyAdaptive Diagnostic Accuracy StudyAdaptive Dose-Response AnalysisAdaptive nested case-controlAdaptive Phase III clinical trialAdaptive Phase IV studyBayesian Phase I clinical trialBayesian Phase II Clinical TrialBayesian Randomized Clinical TrialMatched Randomized Clinical TrialMulticenter Phase III Clinical TrialMulticenter Randomized Clinical TrialPhase I Clinical TrialPhase II clinical trialPhase III clinical trialPragmatic randomized clinical trialProspective Randomized Clinical TrialRisk-adjusted Phase III clinical trial