Process / pipelineComputational neuroscience
Hodgkin-Huxley Model
The Hodgkin-Huxley model is a mathematical description of how action potentials in neurons are generated by the flow of sodium and potassium ions across the cell membrane. Developed by Alan Hodgkin and Andrew Huxley in 1952, it is a foundational model in neuroscience and earned them the Nobel Prize, establishing quantitative biophysics as a discipline.
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Sources
- Hodgkin, A. L., & Huxley, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology, 117(4), 500-544. DOI: 10.1113/jphysiol.1952.sp004764 ↗
- Koch, C. (2004). Biophysics of Computation: Information Processing in Single Neurons. Oxford University Press. link ↗