Process / pipelineSingle-unit electrophysiology
Spike Sorting
Spike sorting is an electrophysiological technique for identifying and isolating action potentials of individual neurons from extracellular electrical recordings. Central to single-unit neurophysiology, spike sorting assigns spikes recorded on electrode arrays to their neuron of origin, enabling study of individual neuron firing patterns, timing, and network interactions with single-cell resolution.
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Sources
- Harris, K. D., Csicsvari, J., Hirase, H., et al. (2016). Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular recordings. Journal of Neurophysiology, 84(1), 401–414. DOI: 10.1152/jn.2000.84.1.401 ↗
- Yger, P., Spampinato, G. L., Esposito, E., et al. (2018). A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo. eLife, 7, e34518. DOI: 10.7554/eLife.34518 ↗