Multi-omics gene set enrichment analysis
Multi-omics gene set enrichment analysis (multi-omics GSEA) is a computational pipeline that applies GSEA logic simultaneously across two or more molecular measurement layers — such as transcriptomics, proteomics, and metabolomics — to identify biological pathways or gene sets that are coordinately dysregulated across omics platforms. By integrating ranked molecular signatures from each layer, it reveals pathway-level convergence that no single omics platform could detect alone.
Kilderegistrering
Citater kopieret ordret fra metodens kilderegistrering. Ingen påstandsniveauverifikation er udledt heraf.
- Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550. · DOI 10.1073/pnas.0506580102
- Meng, C., Zeleznik, O. A., Thallinger, G. G., Kuster, B., Gholami, A. M., & Culhane, A. C. (2016). Dimension reduction techniques for the integrative analysis of multi-omics data. Briefings in Bioinformatics, 17(4), 628–641. · DOI 10.1093/bib/bbv108
Kuraterede påstande
Påstande gemt i bevis-loggen, hver med sin egen vurdering.
Denne visning opfinder ikke en påstandsvurdering, når loggen ingen har.
Relaterede metoder
Genereret fra metodegrafen og vist som maskinelt foreslåede relationer — ingen bevispåstand er udledt.