Process / pipelineHypothesis testing
Tajima's D (选择扫描)
Tajima's D 是一种统计检验，旨在根据 DNA 序列的遗传变异模式来检测选择性扫描——即有利突变的近期快速固定。该检验由 Fumio Tajima 于 1989 年开发，通过比较 DNA 序列多样性的不同度量来衡量偏离中性进化的程度。显著的 Tajima's D 值表明偏离中性进化，提示存在正选择、群体结构或人口统计学事件。
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来源
- Tajima, F. (1989). Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics, 123(3), 585–595. DOI: 10.1093/genetics/123.3.585 ↗
- Braverman, J. M., Hudson, R. R., Kaplan, N. L., Langley, C. H., & Stephan, W. (1995). The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics, 140(2), 783–796. DOI: 10.1093/genetics/140.2.783 ↗
- Fay, J. C., & Wu, C. I. (2000). Hitchhiking under positive Darwinian selection. Genetics, 155(3), 1405–1413. DOI: 10.1093/genetics/155.3.1405 ↗
如何引用本页
ScholarGate. (2026, June 3). Selective Sweep Detection using Tajima's D Statistic. ScholarGate. https://scholargate.app/zh/genetics/selection-sweep
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