Process / pipeline3D genomics
Hi-C 分析
Hi-C（高染色质构象捕获）是一种用于绘制细胞内基因组三维结构的技术及其相关的计算方法。Hi-C 由 Lieberman-Aiden 和 Dekker 于 2009 年开发，可识别基因组区域之间在三维细胞核空间中空间上邻近但线性序列上可能相距遥远的物理相互作用。Hi-C 分析揭示了基因组组织的基本原理，包括拓扑关联域（TADs）的存在，并提供了关于三维结构如何调控基因表达和 DNA 复制的见解。
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来源
- Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., & Dekker, J. (2009). Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science, 326(5950), 289–293. DOI: 10.1126/science.1181369 ↗
- Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., & Ren, B. (2012). Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature, 485(7398), 376–380. DOI: 10.1038/nature11082 ↗
- Szabo, Q., Bantignies, F., & Cavalli, G. (2019). 3D chromatin architecture. Nature Reviews Molecular Cell Biology, 20(4), 207–220. link ↗
如何引用本页
ScholarGate. (2026, June 3). Hi-C Analysis of 3D Genome Organization and Chromatin Interactions. ScholarGate. https://scholargate.app/zh/genetics/hi-c-analysis
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