方法证据记录
Sequence Alignment
Sequence alignment is a foundational bioinformatics technique that arranges two or more DNA, RNA, or protein sequences to reveal regions of similarity, infer evolutionary relationships, identify functional domains, and map sequencing reads to reference genomes. It underpins virtually every downstream genomic analysis, from variant calling and gene expression quantification to phylogenetics and structural annotation.
源记录
引文逐字复制自方法源记录。这些引文不代表任何层级的验证。
Biological Sequence Alignment
分类方法记录 · process-pipeline / bioinformatics
- Needleman, S. B., & Wunsch, C. D. (1970). A general method applicable to the search for similarities in the amino acid sequence of two proteins. Journal of Molecular Biology, 48(3), 443–453. · DOI 10.1016/0022-2836(70)90057-4
- Smith, T. F., & Waterman, M. S. (1981). Identification of common molecular subsequences. Journal of Molecular Biology, 147(1), 195–197. · DOI 10.1016/0022-2836(81)90087-5
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