方法对比
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| 时间序列微生物组多样性分析× | 多组学微生物多样性分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2010s (formalized with 16S amplicon sequencing era; expanded ~2012–2020) | 2010s–present |
| 提出者≠ | Developed iteratively through the microbiome research community; key contributions from Susan Holmes, Rob Knight, and colleagues | Developed collectively; key frameworks by Le Cao et al. (mixOmics, 2017) and Argelaguet et al. (MOFA, 2018) |
| 类型≠ | Longitudinal observational / bioinformatics pipeline | Integrative computational pipeline |
| 开创性文献≠ | Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016). DADA2: High-resolution sample inference from Illumina amplicon data. Nature Methods, 13(7), 581–583. DOI ↗ | Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for 'omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752. DOI ↗ |
| 别名 | longitudinal microbiome diversity analysis, temporal microbiome analysis, repeated-measures microbiome diversity, time-course microbiome analysis | multi-omics microbiome profiling, integrated microbiome omics, multi-modal microbiome analysis, microbiome multi-omics integration |
| 相关 | 5 | 5 |
| 摘要≠ | Time-series microbiome diversity analysis tracks how the richness, evenness, and community composition of microbial communities change across multiple time points within the same subjects. By combining standard diversity metrics with longitudinal statistical models, it separates true temporal dynamics from inter-individual variation, identifying when and how perturbations such as diet changes, antibiotic treatment, or disease onset reshape the microbiome. | Multi-omics microbiome diversity analysis integrates two or more omic data layers — such as metagenomics, metatranscriptomics, metabolomics, and metaproteomics — to characterise both the composition and functional activity of microbial communities. By linking taxonomic diversity metrics with molecular phenotype data, the approach uncovers how community structure translates into ecological and host-relevant functions that no single omic layer can reveal alone. |
| ScholarGate数据集 ↗ |
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