方法对比

	风险调整巢式病例对照研究	Cox比例风险模型
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1977 (nested case-control); risk-adjusted extensions 1980s–2000s	1972
提出者	Thomas (1977) for nested case-control; risk adjustment extensions developed through pharmacoepidemiology literature (1980s–2000s)	Sir David Roxbee Cox
类型	Observational analytical study design	Semi-parametric regression model
开创性文献	Thomas, D. C. (1977). Addendum to: Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society, Series A, 140(4), 469–491.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
别名	risk-adjusted NCC, covariate-adjusted nested case-control, propensity-score nested case-control, nested case-control with risk adjustment	Cox regression, Cox PH model, proportional hazards model, CPH
相关	4	5
摘要	A risk-adjusted nested case-control study embeds a case-control comparison inside a defined cohort and explicitly accounts for differences in baseline risk between cases and controls through covariate adjustment — most commonly via risk scores, propensity scores, or stratification. It preserves the efficiency advantages of the nested design while reducing confounding attributable to pre-existing risk differentials, making it especially valuable in pharmacoepidemiology and clinical effectiveness research.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.