方法对比
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| 生存研究的功效分析× | Cox比例风险模型× | |
|---|---|---|
| 领域≠ | 统计学 | 流行病学 |
| 方法族≠ | Hypothesis test | Process / pipeline |
| 起源年份≠ | 1981 | 1972 |
| 提出者≠ | — | Sir David Roxbee Cox |
| 类型≠ | Sample size determination for survival outcomes | Semi-parametric regression model |
| 开创性文献≠ | Schoenfeld, D. A. (1981). The asymptotic properties of nonparametric tests for comparing survival distributions. Biometrika, 68(1), 316–319. DOI ↗ | Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗ |
| 别名 | log-rank power analysis, cox regression power analysis, survival power analysis, Sağkalım Analizi Güç Analizi | Cox regression, Cox PH model, proportional hazards model, CPH |
| 相关≠ | 6 | 5 |
| 摘要≠ | Power analysis for survival studies determines how many participants — and how many observed events — are required so that a log-rank test or Cox regression has a sufficient probability of detecting a clinically meaningful difference in survival between groups. The foundational formulas were derived by Schoenfeld (1981) and Lachin (1981) and remain the standard approach in clinical trial planning. | The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research. |
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