方法对比

	多组学基因集富集分析	多组学通路富集分析
领域	生物信息学	生物信息学
方法族	Process / pipeline	Process / pipeline
起源年份	2005 (GSEA foundation); multi-omics extensions ~2013–2020	2014–2016 (multi-omics extension of enrichment methods established ~2005)
提出者	Extended from Subramanian et al. (2005); multi-omics integration formalized ~2010s	Building on Subramanian et al. (2005); multi-omics integration formalised by Meng et al. and others (~2014–2016)
类型	Integrative enrichment analysis pipeline	Integrative pathway analysis pipeline
开创性文献	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.	Meng, C., Kuster, B., Culhane, A. C., & Gholami, A. M. (2014). A multivariate approach to the integration of multi-omics datasets. BMC Bioinformatics, 15, 162.
别名	multi-omics GSEA, integrated GSEA, cross-omics pathway enrichment, multi-layer GSEA	multi-omics pathway analysis, integrated pathway enrichment, multi-layer pathway enrichment, MOPEA
相关	6	1
摘要	Multi-omics gene set enrichment analysis (multi-omics GSEA) is a computational pipeline that applies GSEA logic simultaneously across two or more molecular measurement layers — such as transcriptomics, proteomics, and metabolomics — to identify biological pathways or gene sets that are coordinately dysregulated across omics platforms. By integrating ranked molecular signatures from each layer, it reveals pathway-level convergence that no single omics platform could detect alone.	Multi-omics pathway enrichment analysis is a bioinformatics pipeline that integrates molecular data from two or more omics layers — such as transcriptomics, proteomics, metabolomics, and epigenomics — and tests whether the combined signal from those layers converges on specific biological pathways more than expected by chance. By considering multiple molecular levels simultaneously, it identifies pathway-level dysregulation that single-omics analyses would miss.