方法对比

	贝叶斯病例交叉设计	病例-交叉设计
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1991 (case-crossover); Bayesian extension ~2000s	1991
提出者	Malcolm Maclure (case-crossover); Bayesian extension developed by Lumley, Sheppard, and colleagues	Malcolm Maclure
类型	Self-matched observational study design with Bayesian inference	Observational epidemiological study design
开创性文献	Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.	Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153.
别名	Bayesian case-crossover, BCCO, Bayesian self-matched design, Bayesian within-person crossover	case-crossover study, CCO design, self-matched case study, within-person crossover case study
相关	2	3
摘要	The Bayesian case-crossover design is a self-matched epidemiological method that estimates the transient effect of a time-varying exposure on the risk of an acute event. Each case serves as their own control, eliminating confounding by time-stable individual characteristics. Bayesian inference replaces or supplements the classical conditional logistic regression, enabling the incorporation of prior knowledge, more stable estimation in sparse data, and full uncertainty quantification via posterior distributions.	The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury.