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自适应病例对照研究×病例对照研究×
领域流行病学流行病学
方法族Process / pipelineProcess / pipeline
起源年份1950s (base design); adaptive extensions developed from the 1970s–1990s1950s (formal methodology); precursors in the 1920s
提出者Builds on Doll & Hill (1950s) case-control foundations; adaptive elements drawn from sequential analysis (Wald, 1947) and group-sequential methods (Armitage, 1975)Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
类型Adaptive observational epidemiological designObservational analytic study design
开创性文献Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
别名adaptive case-control design, sequential case-control study, adaptive observational study, dynamic case-control studycase-referent study, case-control design, retrospective case-control, case-control analysis
相关66
摘要An adaptive case-control study is a case-control design that incorporates pre-specified rules allowing modification of study parameters — such as sample size, case-to-control ratio, or matching criteria — based on interim data, without compromising validity. It combines the efficiency of adaptive methodology with the retrospective exposure-ascertainment logic of classical case-control research, enabling investigators to respond to emerging evidence while the study is ongoing.A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.
ScholarGate数据集
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  1. v1
  2. 2 来源
  3. PUBLISHED

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ScholarGate方法对比: Adaptive Case-Control Study · Case-control study. 于 2026-06-15 检索自 https://scholargate.app/zh/compare