เปรียบเทียบวิธี

	Network-based epigenome-wide association study	การศึกษาความสัมพันธ์ทั่วทั้งจีโนม (GWAS)
สาขาวิชา	ชีวสารสนเทศศาสตร์	ชีวสารสนเทศศาสตร์
ตระกูล	Process / pipeline	Process / pipeline
ปีกำเนิด	2010s, consolidating 2012–2018	2005–2007
ผู้ริเริ่ม	Adapted from EWAS (Rakyan et al., 2011) and network-based genomic methods (e.g., Ideker & Sharan, 2008)	Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007)
ประเภท	Integrative epigenomic analysis	Observational genomic association study
แหล่งต้นตำรับ	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.	Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661–678.
ชื่อเรียกอื่น	network EWAS, network-integrated EWAS, graph-based EWAS, network-based DNA methylation analysis	GWAS, genome-wide association analysis, whole-genome association study, WGAS
ที่เกี่ยวข้อง	6	6
สรุป	Network-based EWAS extends conventional epigenome-wide association studies by overlaying differentially methylated positions or regions onto biological interaction networks — such as protein-protein interaction, co-expression, or gene regulatory networks — to identify functionally coherent epigenetic modules rather than isolated CpG hits. This integration increases statistical power for detecting weak signals and reveals coordinated epigenetic dysregulation across pathways.	A genome-wide association study (GWAS) systematically tests hundreds of thousands to millions of single-nucleotide polymorphisms (SNPs) across the human genome for statistical association with a trait or disease. By comparing allele frequencies between cases and controls — or by regressing SNP genotypes on a quantitative phenotype — GWAS identifies genomic loci that harbor common genetic variants contributing to complex traits. Since its large-scale debut in 2007, GWAS has catalogued thousands of robust disease–variant associations across virtually every common human condition.