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교차 적응 실험×다중 기저선 설계×
분야실험설계실험설계
계열Process / pipelineProcess / pipeline
기원 연도Late 1990s–2000s1968
창시자Developed through convergence of crossover trial methodology (Senn, Williams) and adaptive design methods (Bauer, Köhne, Chow, Chang)Donald M. Baer, Montrose M. Wolf, Todd R. Risley
유형Experimental design — hybrid adaptive/crossoverSingle-subject experimental design
원전Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584888468Baer, D. M., Wolf, M. M., & Risley, T. R. (1968). Some current dimensions of applied behavior analysis. Journal of Applied Behavior Analysis, 1(1), 91–97. DOI ↗
별칭adaptive crossover trial, adaptive crossover design, crossover adaptive trial, ACE designMBD, multiple-baseline single-case design, staggered baseline design, multiple-probe design
관련54
요약An adaptive crossover experiment combines the within-subject efficiency of crossover designs — where each participant receives multiple treatments in sequence — with pre-specified adaptive rules that allow trial parameters to be modified based on interim data. Each participant acts as their own control across treatment periods, while ongoing accumulating evidence can trigger pre-planned changes such as sample size re-estimation, treatment arm dropping, or allocation ratio adjustment, all governed by a formal adaptation plan to preserve inferential validity.The multiple baseline design is a single-subject experimental design that demonstrates functional control by introducing an intervention at staggered time points across two or more baselines — typically across different behaviors, individuals, or settings. Because no withdrawal of treatment is required, it is especially suitable when the target behavior is irreversible or when removing an effective intervention would be unethical.
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