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	ベイジアンChIP-seqピークコーリング	経路濃縮解析
分野	バイオインフォマティクス	バイオインフォマティクス
系統	Process / pipeline	Process / pipeline
提唱年	2008–2009	2003–2005
提唱者	Spyrou et al. (BayesPeak, 2009); broader Bayesian ChIP-seq framework developed across multiple groups ~2008–2012	Mootha et al. (2003); systematised by Subramanian et al. (2005)
種類	Probabilistic signal detection pipeline	Statistical functional annotation method
原典	Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., & Liu, X. S. (2008). Model-based analysis of ChIP-Seq (MACS). Genome Biology, 9(9), R137.	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.
別名	Bayesian ChIP-seq analysis, probabilistic peak detection, Bayesian peak caller, ChIP-seq Bayesian enrichment calling	PEA, overrepresentation analysis, ORA, functional enrichment analysis
関連	6	6
概要	Bayesian ChIP-seq peak calling applies probabilistic models — typically Poisson, negative binomial, or hidden Markov models with Bayesian inference — to detect genomic regions enriched for a protein of interest in chromatin immunoprecipitation followed by sequencing experiments. By explicitly modelling read-count noise and incorporating prior distributions, Bayesian callers yield posterior probabilities of enrichment rather than simple p-values, providing a principled framework for uncertainty quantification across the genome.	Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments.