Usporedite metode

	Analiza obogaćenja skupova gena potpomognuta strojnim učenjem	Analiza obogaćenja genskih skupova (GSEA)
Područje	Bioinformatika	Bioinformatika
Obitelj	Process / pipeline	Process / pipeline
Godina nastanka	2005 (GSEA); ML integration from ~2015 onward	2005 (seminal PNAS paper; predecessor concept in Mootha et al. 2003)
Tvorac	Subramanian et al. (GSEA foundation, 2005); various ML extensions thereafter	Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Jill P. Mesirov, Todd R. Golub, Eric S. Lander et al. (Broad Institute)
Vrsta	Computational enrichment analysis with machine learning	Functional genomics / enrichment analysis
Temeljni izvor	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.
Drugi nazivi	ML-GSEA, deep learning pathway enrichment, neural GSEA, ML-assisted pathway analysis	GSEA, gene-set analysis, functional enrichment analysis, pathway-level enrichment
Srodne	6	5
Sažetak	Machine learning-assisted gene set enrichment analysis (ML-GSEA) extends the classical GSEA framework by incorporating supervised or unsupervised ML models — such as random forests, neural networks, or deep learning architectures — to improve the detection, ranking, and biological interpretation of enriched gene sets from high-throughput expression data. The approach is particularly valuable for complex, non-linear gene-set relationships that classical enrichment statistics may miss.	Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether a predefined set of genes — representing a biological pathway, process, or function — shows statistically significant, coordinated differences between two biological conditions. Unlike simple fold-change filtering, GSEA operates on all measured genes ranked by a correlation metric, detecting subtle but consistent shifts across an entire pathway even when no single gene passes a significance threshold.