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Dose-Response Analysis — Quantifying How Exposure Level Relates to Outcome Risk

Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.

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  1. Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
  2. Greenland, S., & Longnecker, M. P. (1992). Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. American Journal of Epidemiology, 135(11), 1301–1309. DOI: 10.1093/oxfordjournals.aje.a116237

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ScholarGate. (2026, June 3). Dose-Response Analysis in Epidemiology and Toxicology. ScholarGate. https://scholargate.app/et/epidemiology/dose-response-analysis

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ScholarGateDose-Response Analysis (Dose-Response Analysis in Epidemiology and Toxicology). Loetud 2026-06-15 aadressilt https://scholargate.app/et/epidemiology/dose-response-analysis · Andmestik: https://doi.org/10.5281/zenodo.20539026