Latent structureEpidemiological Design
Case-Cohort Design
Case-cohort design is an epidemiological study design developed by Prentice (1986) that efficiently combines features of case-control and cohort studies. Researchers enroll an entire cohort, follow it for outcomes, then measure exposures only on cases and a random subcohort, reducing measurement costs while maintaining valid causal inference.
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Sources
- Prentice, R. L. (1986). A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika, 73(1), 1-11. DOI: 10.1093/biomet/73.1.1 ↗
- Barlow, W. E., Ichikawa, L., Rosner, D., & Izumi, S. (1999). Analysis of case-cohort designs. Journal of Clinical Epidemiology, 52(12), 1165-1172. DOI: 10.1016/S0895-4356(99)00102-X ↗
- Kang, S., & Cai, J. (2009). Spatial matched-pair cohort studies. Biometrics, 65(2), 526-534. DOI: 10.1111/j.1541-0420.2008.01091.x ↗