Process / pipelineFormulation Technology
Solid Dispersion Formulation
Solid dispersion is a formulation technique where a poorly soluble drug is molecularly dispersed in a hydrophilic polymer matrix, improving aqueous solubility and bioavailability. Introduced by Chiou and Riegelman in 1971, solid dispersions remain a key strategy for overcoming solubility-limited absorption.
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Sources
- Chiou, W. L., Riegelman, S. (1971). Pharmaceutical applications of solid dispersions. Journal of Pharmaceutical Sciences, 60(9), 1281-1302. DOI: 10.1002/jps.2600600902 ↗
- Vasconcelos, T., Sarmento, B., & Costa, P. (2007). Solid dispersions as strategy to improve oral bioavailability of poorly water soluble drugs. Drug Discovery Today, 12(23-24), 1068-1075. DOI: 10.1016/j.drudis.2007.09.005 ↗