Process / pipelineSeparation
Recrystallization
Recrystallization is a classical purification technique in which a solid compound is dissolved in hot solvent, then allowed to crystallize upon cooling, yielding pure crystals while impurities remain in solution. Practiced for centuries in chemistry laboratories, recrystallization remains one of the most effective and accessible methods for purifying organic solids, especially when the target compound has low solubility at low temperatures.
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Sources
- Pavia, D. L., Lampman, G. M., Kriz, G. S., & Engel, R. G. (2014). A Small-Scale Approach to Organic Laboratory Techniques (4th ed.). Cengage Learning. ISBN: 978-1285749297
- Still, W. C., Kahn, M., & Mitra, A. (1978). Rapid chromatographic purification based on solvent-induced density differences and easy detection. The Journal of Organic Chemistry, 43(14), 2923–2925. DOI: 10.1021/jo00408a041 ↗