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Adaptiv dosis-respons-analyse

Adaptiv dosis-respons-analyse kombinerer forudspecificeret dosis-respons-modellering med planlagte interimanalyse, der tillader modifikationer — såsom at fjerne ineffektive doser eller omfordele stikprøvestørrelse — samtidig med at den statistiske integritet opretholdes. Det mest citerede rammeværk er MCP-Mod (Multiple Comparisons and Modeling), som er godkendt af EMA og FDA som en egnet metode til dosis-finding-studier i lægemiddeludvikling.

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Kilder

  1. Bretz, F., Pinheiro, J. C., & Branson, M. (2005). Combining multiple comparisons and modeling techniques in dose-response studies. Biometrics, 61(3), 738-748. DOI: 10.1111/j.1541-0420.2005.00344.x
  2. Bornkamp, B., Bretz, F., Dmitrienko, A., Enas, G., Gaydos, B., Hsu, C. H., König, F., Mohberg, M., Pinheiro, J., Roessner, L., & Smith, M. (2007). Innovative approaches for designing and analyzing adaptive dose-ranging studies. Journal of Biopharmaceutical Statistics, 17(6), 965-995. DOI: 10.1080/10543400701643848

Sådan citerer du denne side

ScholarGate. (2026, June 3). Adaptive Dose-Response Analysis. ScholarGate. https://scholargate.app/da/epidemiology/adaptive-dose-response-analysis

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ScholarGateAdaptive Dose-Response Analysis (Adaptive Dose-Response Analysis). Hentet 2026-06-15 fra https://scholargate.app/da/epidemiology/adaptive-dose-response-analysis · Datasæt: https://doi.org/10.5281/zenodo.20539026