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Maskinlæringsassisteret RNA-seq-analyse af differentiel ekspression

Maskinlæringsassisteret RNA-seq-analyse af differentiel ekspression supplerer klassisk statistisk DE-test (DESeq2, edgeR, limma-voom) med ML-modeller — herunder neurale netværk, random forests og variationelle autoencoders — for bedre at håndtere den høje dimensionalitet, nul-inflation og batch-effekter, der er iboende i RNA-seq-tælledata. Tilgangen forbedrer feature-selektion, støjreduktion og detektionskraft, især i store eller komplekse eksperimentelle designs.

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  1. Lopez, R., Regier, J., Cole, M. B., Jordan, M. I., & Yosef, N. (2018). Deep generative modeling for single-cell transcriptomics. Nature Methods, 15(12), 1053–1058. link
  2. Eraslan, G., Simon, L. M., Mircea, M., Mueller, N. S., & Theis, F. J. (2019). Single-cell RNA-seq denoising using a deep count autoencoder. Nature Communications, 10(1), 390. link

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ScholarGate. (2026, June 3). Machine Learning-Assisted RNA-seq Differential Expression Analysis. ScholarGate. https://scholargate.app/da/bioinformatics/machine-learning-assisted-rna-seq-differential-expression

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ScholarGateMachine learning-assisted RNA-seq differential expression (Machine Learning-Assisted RNA-seq Differential Expression Analysis). Hentet 2026-06-15 fra https://scholargate.app/da/bioinformatics/machine-learning-assisted-rna-seq-differential-expression · Datasæt: https://doi.org/10.5281/zenodo.20539026