方法证据记录
Multi-omics proteomics analysis
Multi-omics proteomics analysis integrates protein abundance data from mass spectrometry with at least one additional omics layer — such as genomics, transcriptomics, or metabolomics — to build a systems-level view of biological regulation. Rather than analyzing proteins in isolation, this approach correlates proteomic profiles with upstream molecular events (e.g., DNA variants, mRNA levels) and downstream functional readouts (e.g., metabolite concentrations), enabling discovery of regulatory drivers that single-omics analyses would miss.
源记录
引文逐字复制自方法源记录。这些引文不代表任何层级的验证。
Multi-Omics Integrative Proteomics Analysis
分类方法记录 · process-pipeline / bioinformatics
- Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752. · DOI 10.1371/journal.pcbi.1005752
- Singh, A., Shannon, C. P., Gautier, B., Rohart, F., Vacher, M., Tebbutt, S. J., & Le Cao, K.-A. (2019). DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays. Bioinformatics, 35(17), 3055–3062. · DOI 10.1093/bioinformatics/bty1054
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